Apparatus and method for pacing mode switching during atrial tachyarrhythmias

ABSTRACT

A method for operating a cardiac pacemaker in which the mode of operation of the pacemaker is altered in response to detecting an episode of atrial tachycardia. In accordance with the invention, the pacemaker&#39;s pacing mode is altered in a manner that attempts to maintain hemodynamic stability during the atrial tachycardia. Such a mode switch is particularly applicable to pacemaker patients suffering from some degree of congestive heart failure.

CROSS REFERENCE TO RELATED APPLICATION(S)

This application is a continuation-in-part of the following, commonlyassigned patent applications: U.S. patent application Ser. No.09/748,796 filed on Dec. 26, 2000, now U.S. Pat. No. 7,142,918, and U.S.patent application Ser. No. 09/316,515 filed on May 21, 1999, now U.S.Pat No. 7,062,325, the specifications of which are herein incorporatedby reference in their entirety. This application also incorporates byreference in its entirety U.S. patent application Ser. No. 09/316,588which issued as U.S. Pat. No. 6,285,907.

FIELD OF THE INVENTION

This invention pertains to cardiac pacemakers and methods for operatingsuch devices. In particular, the invention relates to methods forcardiac pacing during an atrial tachyarrhythmia.

BACKGROUND

Congestive heart failure (CHF) is a clinical syndrome in which anabnormality of cardiac function causes cardiac output to fall below alevel adequate to meet the metabolic demand of peripheral tissues. CHFcan be due to a variety of etiologies with that due to ischemic heartdisease being the most common. Some form of cardiac pacing can oftenbenefit CHF patients. For example, sinus node dysfunction resulting inbradycardia can contribute to heart failure which can be corrected withconventional bradycardia pacing. Also, some CHF patients suffer fromsome degree of AV block such that their cardiac output is improved bysynchronizing atrial and ventricular contractions with dual-chamberpacing using a programmed AV delay time (i.e., atrial triggeredventricular pacing or AV sequential pacing).

A common sequela of CHF is dilation of the heart chambers (especiallythe left ventricle) as end-diastolic volume is increased in the body'sattempt to increase stroke volume. The ventricles can then becomestretched and less contractile which actually worsens the heart failure.Stretching of the ventricular wall can also cause slowed conduction ofdepolarization impulses through the ventricle. If conduction velocity isslowed in the left ventricle more than the right, for example, thecontraction of the two ventricles during ventricular systole becomesuncoordinated which lessens pumping efficiency. Some CHF patients alsosuffer from conduction defects of the specialized conduction system ofthe heart (a.k.a. bundle branch blocks) so that a depolarization impulsefrom the AV node reaches one ventricle before the other. In both ofthese situations, cardiac output can be increased by improving thesynchronization of right and left ventricular contractions. Cardiacpacemakers have therefore been developed which provide pacing to bothventricles. (See, e.g., U.S. Pat. No. 4,928,688, issued to Mower andhereby incorporated by reference.)

Due to stretching of the atrial walls caused by the cardiac dilationdescribed above, CHF patients are predisposed to occurrence of atrialtachyarrhythmias. Atrial tachyarrhythmias are cardiac rhythmscharacterized by atrial contractions occurring at a rapid rate, eitherdue to an ectopic excitatory focus or abnormal excitation by normalpacemaker tissue. Atrial tachyarrhythmias can be classified according toincreasing rate into entities that include atrial tachycardia, atrialflutter, and atrial fibrillation. Due to the refractory period of the AVnode, some degree of AV block is usually always present so that theventricular rate is less than the atrial rate if the AV conductionpathway is otherwise intact. In atrial fibrillation, the atriadepolarize in a chaotic fashion with no effective pumping action, andthe ventricles beat both rapidly and irregularly due to conduction ofexcitatory impulses from the fibrillating atria through the AV node. Inatrial tachyarrhythmias, and especially atrial fibrillation, the atriano longer act as effective primer pumps for the ventricles whichdecreases stroke volume, referred to as a loss of atrio-ventricularsynchrony. Also, when the ventricles contract at irregular intervals,the contraction can occur prematurely before diastolic filling iscomplete and decrease the stroke volume for that contraction. An episodeof atrial tachyarrhythmia can thus depress cardiac output and cause suchsymptoms as dyspnea, fatigue, vertigo, and angina. This is especiallyproblematic in CHF patients who are already hemodynamically compromised.

SUMMARY OF THE INVENTION

The present invention relates to a method and system for altering thepacing mode of a pacemaker in order to maintain hemodynamic stabilityduring an atrial tachyarrhythmia such as atrial fibrillation. Theinvention may be especially beneficial to pacemaker patients with CHFwhose hemodynamics are adversely affected by episodes of atrialfibrillation.

In accordance with the invention, the pacing mode of a pacemaker isswitched from a normal pacing mode to an atrial fibrillation pacing modein response to detection of an atrial tachyarrhythmia. The atrialfibrillation pacing mode is adapted for pacing in the presence of anirregular intrinsic ventricular rhythm. Depending upon the individualpatient and the normal pacing mode, the atrial fibrillation mode mayinclude initiation or modification of ventricular resynchronizationtherapy, initiation of ventricular rate regularization pacing, and/orchanges to rate-adaptive parameters.

In one embodiment, the atrial fibrillation mode includes ventricularresynchronization, wherein pacing stimulation is applied to bothventricles or to one ventricle in a manner that improves thecoordination of ventricular contractions. Such pacing is beneficial inpatients with interventricular or intraventricular conduction defects,and switching to a resynchronization mode during an episode of atrialtachyarrhythmia improves cardiac output in those patients. If the normalpacing mode already includes resynchronization therapy, it may bebeneficial to modify the resynchronization in the atrial fibrillationmode by, for example, adjusting a biventricular offset value orinitiating biventricular triggered pacing.

In another embodiment, the atrial fibrillation mode includes ventricularrate regularization where a ventricular escape interval is dynamicallyadjusted in accordance with a measured intrinsic ventricular rate. Byadjusting the ventricular escape interval to more nearly match theintrinsic ventricular rate, more paces are delivered and lessvariability in the overall ventricular rhythm is allowed. With a moreregular ventricular rate, cardiac output is improved during an atrialtachyarrhythmia. Ventricular rate regularization may also enhance theeffectiveness of ventricular resynchronization pacing in the presence ofan atrial tachyarrhythmia by increasing the number of paces delivered.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a system diagram of a microprocessor-based pacemaker.

FIGS. 2A and 2B show an exemplary filter implementation of a ventricularrate regularization system.

FIG. 3 is a block diagram illustrating exemplary atrial fibrillationpacing modes.

DESCRIPTION OF THE INVENTION

The most common condition for which pacemakers are used is in thetreatment of bradycardia, where the ventricular rate is too slow.Atrio-ventricular conduction defects (i.e., AV block) that are fixed orintermittent and sick sinus syndrome represent the most common causes ofbradycardia for which permanent pacing may be indicated. If functioningproperly, a pacemaker makes up for the heart's inability to pace itselfat an appropriate rhythm in order to meet metabolic demand by enforcinga minimum heart rate. As described below, bradycardia pacing modesdefine which chambers are paced and the manner in which the paces aredelivered. Pacing therapy can also be used in the treatment ofcongestive heart failure (CHF). Some CHF patients suffer from somedegree of AV block or are chronotropically deficient such that theircardiac output can be improved with conventional bradycardia pacing. Ithas also been shown, however, that some CHF patients suffer fromintraventricular and/or interventricular conduction defects such thattheir cardiac outputs can be increased by improving the synchronizationof right and left ventricular contractions with electrical stimulation,referred to herein as ventricular resynchronization therapy.

A pacemaker patient with some degree of CHF who experiences an episodeof atrial fibrillation will suffer some diminishing of cardiac outputfrom the resulting irregular ventricular rhythm and/or loss ofatrio-ventricular synchrony. Thus, even if a patient were adequatelytreated during normal circumstances with only a bradycardia pacing mode,the same patient may benefit from resynchronization therapy to restorehemodynamic stability during the atrial fibrillation episode.Furthermore, patients treated with resynchronization therapy in additionto a bradycardia pacing mode may benefit from a modification to thepacing mode including changes to the mode of resynchronization. Thepresent invention relates to a method for operating a pacemaker in whicha normal pacing mode is switched to an atrial fibrillation pacing modeupon detection of an atrial tachyarrhythmia such as atrial fibrillationthat counteracts the adverse effects of atrial fibrillation.

1. Hardware Platform

Cardiac pacemakers are cardiac rhythm management devices that provideelectrical stimulation in the form of pacing pulses to selected chambersof the heart. (As the term is used herein, a pacemaker is any cardiacrhythm management device that performs cardiac pacing, includingimplantable cardioverter/defibrillators having a pacing functionality.)Cardiac rhythm management devices are typically implanted subcutaneouslyin a patient's chest and have leads threaded intravenously into theheart to connect the device to electrodes used for sensing and pacing,the electrodes being disposed in proximity to selected chambers of theheart. Pacemakers typically have a programmable electronic controllerthat causes the pacing pulses to be output in response to lapsed timeintervals and sensed electrical activity (i.e., intrinsic heart beatsnot as a result of a pacing pulse). A depolarization wave associatedwith an intrinsic contraction of the atria or ventricles that isdetected by the pacemaker is referred to as an atrial sense (P wave) orventricular sense (R wave), respectively. In order to cause such acontraction in the absence of an intrinsic beat, a pacing pulse withenergy above a certain pacing threshold is delivered to the chamber.

FIG. 1 shows a system diagram of a microprocessor-based pacemakerphysically configured with sensing and pacing channels for the atriumand both ventricles. The controller 10 of the pacemaker is amicroprocessor which communicates with a memory 12 via a bidirectionaldata bus. The memory 12 typically comprises a ROM (read-only memory) forprogram storage and a RAM (random-access memory) for data storage. Thepacemaker has atrial sensing and pacing channels comprising electrode34, lead 33, sensing amplifier 31, pulse generator 32, and an atrialchannel interface 30 which communicates bidirectionally with a port ofmicroprocessor 10. The device also has ventricular sensing and pacingchannels for both ventricles comprising electrodes 24 a–b, leads 23 a–b,sensing amplifiers 21 a–b, pulse generators 22 a–b, and ventricularchannel interfaces 20 a–b where “a” designates one ventricular channeland “b” designates the other. For each channel, the same lead andelectrode are used for both sensing and pacing. The channel interfaces20 a–b and 30 include analog-to-digital converters for digitizingsensing signal inputs from the sensing amplifiers and registers whichcan be written to by the microprocessor in order to output pacingpulses, change the pacing pulse amplitude, and adjust the gain andthreshold values for the sensing amplifiers. An exertion level sensor330 (e.g., an accelerometer or a minute ventilation sensor) enables thecontroller to adapt the pacing rate in accordance with changes in thepatient's physical activity. A telemetry interface 40 is also providedfor communicating with an external programmer. A pacemaker incorporatingthe present invention may possess all of the components in FIG. 1 and beprogrammable so as to operate in a number of different modes, or it mayhave only those components necessary to operate in a particular mode.

The controller 10 controls the overall operation of the device inaccordance with programmed instructions stored in memory. The controller10 controls the delivery of paces via the pacing channels in accordancewith a pacing mode, interprets sense signals from the sensing channels,and implements timers for defining escape intervals and sensoryrefractory periods. The controller also detects the presence ofarrhythmias such as atrial fibrillation by measuring the time intervalbetween senses and implements the mode switching function as describedherein. It should be appreciated that these functions could also beperformed by custom logic circuitry either in addition to or instead ofa programmed microprocessor.

2. Bradycardia Pacing Modes

Bradycardia pacing modes are generally designated by a letter code ofthree positions where each letter in the code refers to a specificfunction of the pacemaker. The first letter refers to which heartchambers are paced and which may be an A (for atrium), a V (forventricle), D (for both chambers), or O (for none). The second letterrefers to which chambers are sensed by the pacemaker's sensing channelsand uses the same letter designations as used for pacing. The thirdletter refers to the pacemaker's response to a sensed P wave from theatrium or an R wave from the ventricle and may be an I (for inhibited),T (for triggered), D (for dual in which both triggering and inhibitionare used), and O (for no response). Modem pacemakers are typicallyprogrammable so that they can operate in any mode which the physicalconfiguration of the device will allow. Additional sensing ofphysiological data allows some pacemakers to change the rate at whichthey pace the heart in accordance with some parameter correlated tometabolic demand. Such pacemakers are called rate-adaptive pacemakersand are designated by a fourth letter added to the three-letter code, R.

Pacemakers can enforce a minimum heart rate either asynchronously orsynchronously. In asynchronous pacing, the heart is paced at a fixedrate irrespective of intrinsic cardiac activity. There is thus a riskwith asynchronous pacing that a pacing pulse will be deliveredcoincident with an intrinsic beat. Most pacemakers for treatingbradycardia today are therefore programmed to operate synchronously in aso-called demand mode where sensed cardiac events occurring within adefined interval either trigger or inhibit a pacing pulse. Inhibiteddemand pacing modes utilize escape intervals to control pacing inaccordance with sensed intrinsic activity. In an inhibited demand mode,a pacing pulse is delivered to a heart chamber during a cardiac cycleonly after expiration of a defined escape interval during which nointrinsic beat by the chamber is detected. If an intrinsic beat occursduring this interval, the heart is thus allowed to “escape” from pacingby the pacemaker. Such an escape interval can be defined for each pacedchamber. For example, a ventricular escape interval can be definedbetween ventricular events so as to be restarted with each ventricularsense or pace. The inverse of this escape interval is the minimum rateat which the pacemaker will allow the ventricles to beat, sometimesreferred to as the lower rate limit (LRL).

In atrial tracking pacemakers (i.e., VDD or DDD mode), anotherventricular escape interval is defined between atrial and ventricularevents, referred to as the atrioventricular interval (AVI). Theatrio-ventricular interval is triggered by an atrial sense or pace andstopped by a ventricular sense or pace. A ventricular pace is deliveredupon expiration of the atrio-ventricular interval if no ventricularsense occurs before. Atrial-triggered ventricular pacing attempts tomaintain the atrio-ventricular synchrony occurring with physiologicalbeats whereby atrial contractions augment diastolic filling of theventricles. If a patient has a physiologically normal atrial rhythm,atrial-triggered pacing also allows the ventricular pacing rate to beresponsive to the metabolic needs of the bodv. Atrial tracking modes arecontraindicated when there is chronic refractory atrial tachyarrhythmiasuch as atrial fibrillation or atrial flutter.

A pacemaker can also be configured to pace the atria on an inhibiteddemand basis. An atrial escape interval is then defined as the maximumtime interval in which an atrial sense must be detected after aventricular sense or pace before an atrial pace will be delivered. Whenatrial inhibited demand pacing is combined with atrialtriggeredventricular demand pacing (i.e., DDD mode), the lower rate interval isthen the sum of the atrial escape interval and the atrio-ventricularinterval.

Rate-adaptive pacemakers modulate the ventricular and/or atrial escapeintervals base upon measurements corresponding to physical activity.Such pacemakers are applicable to situations in which atrial trackingmodes cannot be use. In a rate-adaptive pacemaker operating in aventricular pacing mode, the LRL is adjusted in accordance with exertionlevel measurements such as from an accelerometer or minute ventilationsensor in order for the heart rate to more nearly match metabolicdemand. The adjusted LRL is then termed the sensor-indicated rate.

3. Ventricular Resynchronization Therapy

In a ventricular resynchronization pacing mode, pacing stimulation isapplied to one or both ventricles in a manner that improves thecoordination of ventricular contractions and thereby improvesventricular pumping efficiency. In delivering such therapy, for example,it may be useful to pace only one ventricle on an inhibited demand basisin accordance with sense signals received from the opposite ventricle,pace one ventricle in a triggered mode in which an intrinsic beat in oneventricle triggers a pace in the opposite ventricle, pace bothventricles on an inhibited demand basis in accordance with sense signalsreceived from only one ventricle, or pace both ventricles in acombination of triggered and inhibited demand modes. In the examples ofresynchronization therapy that follow, the ventricular pacing modes arebased upon intrinsic activity in the right ventricle. It should beappreciated, however, that equivalent embodiments could be applied topacing modes based upon left ventricular intrinsic activity.

One implementation of resynchronization therapy is biventricular (BV)pacing. In BV pacing, a left ventricular pace is delivered eithersimultaneously or in a timed relation with a right ventricle pace asspecified by a biventricular offset interval. The offset interval may bezero in order to pace both ventricles simultaneously, positive in orderto pace the left ventricle after the right, or negative if the leftventricle is paced before the right. In many cases, pumping efficiencyof the heart will be increased by simultaneous pacing of the ventricleswith an offset of zero. However, it may be desirable in certain patientsto pace one ventricle before the other in order to compensate fordifferent conduction velocities in the two ventricles, and this may beaccomplished by specifying a particular biventricular offset interval.The ventricles may be paced on an inhibited demand basis where theventricular escape interval is restarted with either a ventricular paceor a right ventricular sense. The pacing mode may also include atrialtracking. In that case, a pair of ventricular paces are delivered afterexpiration of the AVI escape interval or expiration of the LRL escapeinterval, with ventricular pacing inhibited by a right ventricular sensethat restarts the LRL escape interval or stops the AVI escape interval.Since the ventricular escape interval in this mode is reset or stoppedby senses only from the right ventricle, a left ventricular protectionperiod may be provided that starts with the occurrence of a leftventricular sense and lasts for a specified time. A left ventricularpace is then not permitted upon expiration of the escape interval if itwould occur within the protection period.

A variation of biventricular pacing is to pace only the left ventricle(LV-only pacing). LV-only pacing may be advantageous where theconduction velocities within the ventricles are such that pacing onlythe left ventricle results in a more coordinated contraction by theventricles than with conventional right ventricular pacing orbiventricular pacing. LV-only pacing may be implemented in inhibiteddemand modes with or without atrial tracking, similar to biventricularpacing. A left ventricular pace is then delivered upon expiration of theAVI escape interval or expiration of the LRL escape interval, with leftventricular pacing inhibited by a right ventricular sense that restartsthe LRL escape interval or stops the AVI escape interval. As with BVpacing, a left ventricular pace may be inhibited if a left ventricularsense occurs within a protective period prior to expiration of theventricular escape interval. Since an inhibited left ventricular pace inthis mode could result in a cardiac cycle with no pacing, the mode maybe further modified such that a right ventricular safety pace isdelivered if the left ventricular pace is inhibited and no rightventricular sense has occurred.

Another ventricular resynchronization mode is a biventricular triggered(BT) mode where one or both ventricles are paced within a latency periodfollowing a sense from the right ventricle. In this mode, rather thaninhibiting pacing upon receipt of a right ventricular sense, ventricularpacing is triggered to occur in the shortest time possible after a rightventricular sense in order produce a coordinated contraction of theventricles. This mode of pacing may be desirable when theintraventricular conduction time of the heart is long enough that thepacemaker is able to reliably insert a pace before depolarization fromthe right ventricle would reach the left ventricle. The time delaybetween a right ventricular sense and the ensuing pace output isdictated by the response time of the hardware and is designated as thesense-to-pace latency (SPL) interval. Note that the SPL interval is acharacteristic of the hardware and not a programmable timer interval.The mode may operate such that following a right ventricular sense,either the left ventricle only is paced, or both ventricles are paced.In the latter case, the right ventricle is paced even though a rightventricular sense has been received to allow for the possibility thatthe right ventricular sense was actually a far-field left ventricularsense in the right ventricular channel. If the right ventricular sensewere actually from the right ventricle, the right ventricular pace wouldoccur during the right ventricle's physiological refractory period andbe of no consequence. With either type of BT pacing mode, pacing of theleft ventricle can be inhibited by a left ventricular sense thattriggers a left ventricular protective period interval. Biventriculartriggered pacing can also be combined with biventricular inhibiteddemand pacing.

4. Ventricular Rate Regularization

Ventricular rate regularization (VRR) is a ventricular pacing mode inwhich the LRL of the pacemaker is dynamically adjusted in accordancewith a detected intrinsic ventricular rate. When a pacemaker isoperating in a ventricular pacing mode (e.g., VVI), intrinsicventricular beats occur when the instantaneous intrinsic rate risesabove the LRL of the pacemaker. Otherwise, paces are delivered at a rateequal to the LRL. Thus, paces are interspersed with intrinsic beats, andthe overall ventricular rhythm as a result of both paces and intrinsicbeats is determined by the LRL and the mean value and variability of theintrinsic ventricular rate. VRR regularizes the overall ventricularrhythm by adjusting the LRL of the pacemaker in accordance with changesin the measured intrinsic rate.

The intrinsic ventricular rate is the rate at which intrinsicventricular beats occur and can be defined both instantaneously and asbeing at some mean value with a certain variability about that mean. Theinstantaneous intrinsic rate can be determined by measuring an R—Rinterval, where an R—R interval is the time between a presentventricular sense (i.e., an R-wave or intrinsic ventriculardepolarization) and the preceding ventricular sense or ventricular pace,with the instantaneous rate being the reciprocal of the measuredinterval. The LRL of a pacemaker is initially set to a programmed basevalue and defines the ventricular escape interval, which is the maximumtime between ventricular beats allowed by the pacemaker and is thereciprocal of the LRL. At any particular mean intrinsic rate above theLRL, a ventricular pace is delivered only when, due to the variabilityin the intrinsic rate, an R—R interval would be longer than theventricular escape interval were it allowed to occur. As the meanintrinsic ventricular rate increases above the LRL, fewer paces aredelivered and more variability in the overall ventricular rhythm isallowed. The VRR pacing mode counteracts this by increasing the LRL asthe intrinsic ventricular rate increases to thereby increase thefrequency of paced beats and lessen the variability in the overallventricular rate. The VRR mode then decreases the LRL toward its basevalue as the number of paces delivered increases due to a decrease ineither the mean intrinsic ventricular rate or its variability. The LRLadjusted in this manner is also referred to herein as the VRR-indicatedrate.

In one embodiment of VRR, the LRL is adjusted by measuring an R—Rinterval when a ventricular sense occurs and then computing an updatedventricular escape interval based upon the measured R-R interval. When aventricular pace is delivered, on the other hand, the LRL is made todecay toward the programmed base value. FIGS. 2A and 2B show anexemplary implementation of a VRR system made up of a pair of filters515 and 516 which may be implemented as software executed by thecontroller 10 and/or with discrete components. Filter 515 is employed tocompute the updated ventricular escape interval when a ventricular senseoccurs, and filter 516 is used when a ventricular pace is delivered.

When a ventricular sense occurs, the measured R—R interval is input to arecursive digital filter 515 whose output is the updated ventricularescape interval. The filter 515 multiplies the measured R—R interval bya filter coefficient A and then adds the result to the previous value ofthe output (i.e., the present ventricular escape interval) multiplied bya filter coefficient B. The operation of the filter is thus described byVEI_(n)=A(RR_(n))+B(VEI_(n−1)), where A and B are selected coefficients,RR_(n) is the most recent R—R interval duration, and VEI_(n−1) is theprevious value of the ventricular escape interval. A useful way toconceptualize the filter 515 is to decompose the coefficients A and Binto a scaling factor a and a weighting coefficient w such that A=a·wand B=(1−w), where w is between 0 and 1. Viewed this way, the filter isseen as computing a weighted average of the present R—R intervalmultiplied by the scaling factor a and the present ventricular escapeinterval. The filter thus causes the value of the ventricular escapeinterval to move toward the present R—R interval multiplied by thescaling factor at a rate determined by the weighting coefficient. Thiscorresponds to the filter moving the pacemaker's LRL toward a fraction1/a of the instantaneous intrinsic ventricular rate as determined by themeasured R—R interval. If a ventricular sense has occurred, the currentLRL is necessarily less than the measured instantaneous intrinsicventricular rate. If it is also less than 1/a of the intrinsic rate, theLRL is increased by the filter up to a value that is 1/a of theintrinsic rate to result in more pacing and less variability in theoverall ventricular rhythm.

When a ventricular pace is delivered due to expiration of the venticularescape interval without a ventricular sense, filter 516 multiplies thepresent ventricular escape interval by a filter coefficient C so thatVEI_(n)=C(VEI_(n−1)). To provide stable operation, the coefficient Cmust be set to a value greater than 1. Filter 516 then causes theventricular escape interval to increase in an exponential manner witheach pace as successive values of the escape interval are input to thefilter up to a value corresponding to the base LRL.

The updating of the ventricular escape interval may be performed invarious ways including on a beat-to-beat basis, at periodic intervals,or with averages of successive R—R intervals. In a presently preferredembodiment, however, the updating is performed on a beat-to-beat basiswith each ventricular sense or pace causing adjustment of the LRL byfilter 515 or 516, respectively. The two filters operating together thuscause the LRL to move closer to 1/a of the measured intrinsic rate aftera ventricular sense and to decay toward the base LRL value after aventricular pace.

The coefficients a and w (or A and B) and C are selected by the user andmay be made programmable so that the behavior of the system can beadjusted to produce the clinically best result in an individual patient.For example, as the scaling factor a is made greater than 1, the filter515 causes the LRL to move toward a smaller fraction 1/a of the detectedintrinsic rate which allows more intrinsic beats to occur and greatervariability in the overall rhythm. As a is decreased back toward 1, thefilter 515 tends to move the LRL of the pacemaker toward a largerfraction of the detected instantaneous intrinsic rate, thus increasingthe amount of pacing and decreasing the amount of variability allowed inthe overall ventricular rhythm. If a is made smaller than 1, the LRL ismoved toward a rate higher than the intrinsic rate, further increasingthe amount of pacing to point where most of the ventricular rhythm ismade up of paced beats. The larger the weighting factor w, the fasterthe LRL is moved to the specified fraction of the intrinsic rate, makingthe system more responsive to increases in the variability of theintrinsic rhythm. The larger the decay coefficient C, the more rapidlywill filter 516 cause the LRL to decrease toward its programmed basevalue when ventricular paces are delivered due to no ventricular sensesbeing detected within the ventricular escape interval. The controllerlimits the updated ventricular escape interval as a result of theoperations of filters 515 and 516 to minimum and maximum values inaccordance with a programmed maximum pacing rate MPR and base lower ratelimit LRL, respectively.

As noted, the coefficients of filters 515 and 516 can be madeprogrammable by the user, such as by using a remote programmer. Inanother embodiment, the user selects a desired performance parameter(e.g., desired degree of rate regularization, desired amount of pacing,desired decay rate, etc.) from a corresponding range of possible values.The appropriate combinations of coefficients for filters 515 and 516 arethen automatically selected to provide filter settings that correspondto the selected user-programmed performance parameter. The filtercoefficients can also be made functions of other parameters, such as themeasured R—R interval and current LRL setting, and dynamically adjusted.

The VRR system in this embodiment uses the programmed base LRL of thepacemaker as the lower limit to which the LRL is permitted to decay whenno ventricular senses are detected. The base LRL can be changedperiodically by the user with an external programmer, and rate-adaptivepacemakers have the capability of dynamically adjusting the LRL in orderto adapt to exercise. If a rate-adaptive pacemaker is operated in a VRRmode, the sensor-indicated rate can simply be regarded by the pacemakeras the base LRL. The lower limit for the VRR-indicated rate is then thesensor-indicated rate rather than the programmed base LRL.

5. Pacing Mode Switching During Atrial Fibrillation

FIG. 3 is a block diagram illustrating examples of an atrialfibrillation pacing mode that is switched to upon detection of an atrialtachyarrhythmia. An atrial tachyarrhythmia, such as atrial fibrillation,is detected at block 300 while the pacemaker is operating in its normalmode. Atrial triggered ventricular pacing is contraindicated during anatrial tachyarrhythmia because atrial rate tracking would result inventricular pacing that is too rapid. If the normal mode incorporatesatrial tracking and/or atrial pacing, therefore, the atrial fibrillationmode includes a reversion to a non-atrial triggered ventricular pacingmode (i.e., VVx mode) as shown at block 301. The atrial fibrillationmode may also include one or more other pacing modes, each of which willbe discussed in turn.

The atrial fibrillation mode may include initiation of ventricular rateregularization as shown at block 302. If AV conduction is intact in apatient, atrial fibrillation results in a very rapid and intrinsicventricular rhythm, and regularizing the ventricular rate improvescardiac output directly through its effect on diastolic filling.Ventricular rate regularization may be applied in this instance withparameter settings such that the ventricles are driven at a rate nearthe intrinsic rate. The intrinsic ventricular rhythm that occurs duringan episode of atrial fibrillation is a result of the chaoticallyoccurring depolarizations occurring in the atria being passed throughthe AV node to the ventricles. The intrinsic ventricular rate is thusgoverned by the cycle length of the atrial fibrillation and therefractory period of the AV node. If a ventricular pacing pulse isdelivered before the next intrinsic beat occurs, the ventriculardepolarization is conducted retrogradely to the AV node causing latedepolarization of the AV node during the ventricular beat. Therefractory period of the AV node is also delayed, which delays the timebefore an atrial depolarization can be conducted through the node toresult in an intrinsic beat. The effect of the pace is thus to lengthenthe time until the next intrinsic beat. Ventricular rate regularizationat a pacing rate near the intrinsic ventricular rate is thus especiallyeffective at regularizing the ventricular rate during atrialfibrillation.

Ventricular resynchronization therapy may also be initiated as part ofthe atrial fibrillation mode. In pacemaker patients having some degreeof interventricular or intraventricular conduction delays, a ventricularresynchronization pacing mode can improve cardiac output by improvingthe coordination of ventricular contractions. Although cardiac outputmay be adequate in some of these patients during normal circumstanceseven without ventricular resynchronization pacing, an episode of atrialfibrillation with loss of atrio-ventricular synchrony and irregulardiastolic filling may cause the conduction deficits to become clinicallyevident. Switching the pacemaker to a ventricular resynchronizationpacing mode may then be helpful in maintaining cardiac output whenatrial fibrillation is detected.

Resynchronization pacing as incorporated into the atrial fibrillationmode may be delivered in a number of different pacing modes. One suchresynchronization pacing mode is biventricular pacing with or without anoffset interval. This mode can be combined with the reverted to VVIbradycardia pacing mode to result in biventricular pacing on aninhibited demand basis as depicted at block 304. Other alternatives forthe atrial fibrillation mode are biventricular-triggered and LV-onlypacing modes as shown by blocks 306 and 303, respectively.Biventricular-triggered resynchronization pacing may be particularlyuseful when the intrinsic ventricular rate is irregular as it allowsreliable delivery of resynchronization pulses based upon the irregularrate. It may also be advantageous to combine resynchronization pacingwith ventricular rate regulation as the ventricular rate regulation canbe set to increase the amount of pacing and, therefore, the amount ofresynchronization. If ventricular resynchronization is part of thenormal pacing mode, the atrial fibrillation mode may then includeparticular modification of resynchronization pacing parameters such asadjustments to the biventricular offset interval designated by block305, or switching to an alternative resynchronization pacing mode orswitching to additional or alternate pacing sites.

The diminished cardiac output that occurs during atrial fibrillation canalso be partially counteracted by making the pacing rate responsive tomeasured exertion levels. Accordingly, the atrial fibrillation mode mayalso include switching from non-rate adaptive to rate-adaptive pacing asshown at block 308, and/or modification of rate-adaptive parameters asshown at block 307. In the latter case, for example, the rate-responsecurve that maps a given exertion level to a particular pacing rate maybe adjusted to make the pacemaker more responsive, and/or the base lowerrate limit corresponding to a resting exertion level could be increased.

Although the invention has been described in conjunction with theforegoing specific embodiment, many alternatives, variations, andmodifications will be apparent to those of ordinary skill in the art.Such alternatives, variations, and modifications are intended to fallwithin the scope of the following appended claims.

1. A method for operating a cardiac pacemaker, comprising: sensingatrial depolarizations through an atrial sensing channel; sensingventricular depolarizations through one or more ventricular sensingchannels; pacing a ventricle in accordance with a particular primarypacing mode; switching the pacemaker to an atrial fibrillation pacingmode upon detection of an atrial tachyarrhythmia, wherein the atrialfibrillation mode includes ventricular resynchronization pacing andadjustment of a ventricular escape interval in order to regularize therate at which ventricular beats occur; and, adjusting the ventricularescape interval in the atrial fibrillation pacing mode by increasing theventricular escape interval after each ventricular pace is delivered anddecreasing the ventricular escape interval after each ventricular sense.2. The method of claim 1 wherein the adjustment of the ventricularescape interval is based on a previous value of the ventricular escapeinterval and a measured intrinsic ventricular rate.
 3. The method ofclaim 1 wherein the adjustment of the ventricular escape interval isperformed by increasing the ventricular escape interval after eachventricular pace is delivered and decreasing the ventricular escapeinterval after each ventricular sense by computing a weighted average ofa previous value of the ventricular escape interval and an RR interval,where the RR interval is the interval between the ventricular sense andthe preceding ventricular sense or pace.
 4. The method of claim 1wherein the ventricular resynchronization pacing is biventricular pacingwith a selected biventricular offset interval.
 5. The method of claim 4wherein the adjustment of the ventricular escape interval is based on aprevious value of the ventricular escape interval and a measuredintrinsic ventricular rate which increases the ventricular escapeinterval after a ventricular pace is delivered and decreases theventricular escape interval after a ventricular sense.
 6. The method ofclaim 5 wherein the pacemaker is normally operated in a primary pacingmode that includes atrial-triggered ventricular pacing, and whereinswitching to an atrial fibrillation mode includes reverting to anon-atrial triggered ventricular pacing mode.
 7. The method of claim 5wherein the primary pacing mode includes ventricular resynchronizationpacing which is different from the ventricular resynchronization pacingin the atrial fibrillation mode.
 8. The method of claim 5 wherein theprimary pacing mode is a single ventricle pacing mode which does notinclude ventricular resynchronization pacing.
 9. A cardiac pacemaker,comprising: an atrial sensing channel for sensing atrialdepolarizations; a ventricular sensing channel for sensing ventriculardepolarizations; right and left pacing channels for delivering paces tothe right and left ventricles; a controller for controlling the deliveryof paces in accordance with a primary pacing mode; wherein thecontroller is configured to switch the pacemaker to an atrialfibrillation pacing mode upon detection of an atrial tachyarrhythmia,wherein the atrial fibrillation pacing mode includes ventricularresynchronization pacing and adjustment of a ventricular escape intervalin order to regularize the rate at which ventricular beats occur; and,wherein the controller is configured to adjust the ventricular escapeinterval in the atrial fibrillation pacing mode by increasing theventricular escape interval after each ventricular pace is delivered anddecreasing the ventricular escape interval after each ventricular sense.10. The pacemaker of claim 9 wherein the adjustment of the ventricularescape interval is based on a previous value of the ventricular escapeinterval and a measured intrinsic ventricular rate.
 11. The pacemaker ofclaim 9 wherein the adjustment of the ventricular escape interval isperformed by increasing the ventricular escape interval after eachventricular pace is delivered and decreasing the ventricular escapeinterval after each ventricular sense by computing a weighted average ofa previous value of the ventricular escape interval and an RR interval,where the RR interval is the interval between the ventricular sense andthe preceding ventricular sense or pace.
 12. The pacemaker of claim 9wherein the ventricular resynchronization pacing is biventricular pacingwith a selected biventricular offset interval.
 13. The pacemaker ofclaim 12 wherein the adjustment of the ventricular escape interval isbased on a previous value of the ventricular escape interval and ameasured intrinsic ventricular rate which increases the ventricularescape interval after a ventricular pace is delivered and decreases theventricular escape interval after a ventricular sense.
 14. The pacemakerof claim 13 wherein the pacemaker is normally operated in a primarypacing mode that includes atrial-triggered ventricular pacing, andwherein switching to an atrial fibrillation mode includes reverting to anon-atrial triggered ventricular pacing mode.
 15. The pacemaker of claim13 wherein the primary pacing mode includes ventricularresynchronization pacing which is different from the ventricularresynchronization pacing in the atrial fibrillation mode.
 16. Thepacemaker of claim 13 wherein the primary pacing mode is a singleventricle pacing mode which does not include ventricularresynchronization pacing.
 17. The pacemaker of claim 9 wherein theadjustment of the ventricular escape interval is performed by increasingthe ventricular escape interval after each ventricular pace is deliveredby an amount depending upon a previous value of the ventricular escapeinterval.
 18. The pacemaker of claim 17 wherein the adjustment of theventricular escape interval is performed by increasing the ventricularescape interval after each ventricular pace is delivered by multiplyinga previous value of the ventricular escape interval by a specifiedcoefficient.
 19. The method of claim 9 wherein the adjustment of theventricular escape interval is performed by increasing the ventricularescape interval after each ventricular pace is delivered by an amountdepending upon a previous value of the ventricular escape interval. 20.The method of claim 19 wherein the adjustment of the ventricular escapeinterval is performed by increasing the ventricular escape intervalafter each ventricular pace is delivered by multiplying a previous valueof the ventricular escape interval by a specified coefficient.